KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
35.76
Human Site:
T263
Identified Species:
56.19
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
T263
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Chimpanzee
Pan troglodytes
XP_509323
803
92478
T263
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
T263
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
T263
S
D
Y
L
E
L
D
T
I
K
N
L
V
R
K
Rat
Rattus norvegicus
Q66HD0
804
92752
T263
S
D
Y
L
E
L
D
T
I
K
N
L
V
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
T281
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Chicken
Gallus gallus
P08110
795
91537
T262
S
D
Y
L
E
L
D
T
V
K
N
L
V
K
K
Frog
Xenopus laevis
NP_001083114
805
92996
T263
T
D
Y
L
E
L
E
T
I
K
N
L
V
R
K
Zebra Danio
Brachydanio rerio
Q90474
725
83300
E237
E
E
G
E
K
Q
E
E
E
E
V
A
A
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
G230
A
D
D
E
K
K
E
G
D
E
K
K
E
M
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
E215
L
V
V
E
K
E
R
E
K
E
V
E
D
E
E
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
T262
Y
D
F
L
E
A
D
T
I
E
N
L
V
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
E228
T
E
K
T
T
E
K
E
I
S
D
D
E
E
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
K264
G
E
Y
L
E
E
S
K
L
K
E
L
V
K
R
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
P218
K
E
V
E
K
E
V
P
I
P
E
E
E
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
100
93.3
80
0
N.A.
6.6
N.A.
0
73.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
100
33.3
N.A.
40
N.A.
26.6
86.6
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
6.6
N.A.
46.6
20
N.A.
P-Site Similarity:
N.A.
40
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
0
0
0
0
0
7
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
67
7
0
0
0
54
0
7
0
7
7
7
0
0
% D
% Glu:
7
27
0
27
67
27
20
20
7
27
14
14
20
14
27
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
7
0
0
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
67
0
0
0
0
0
0
% I
% Lys:
7
0
7
0
27
7
7
7
7
60
7
7
0
54
67
% K
% Leu:
7
0
0
67
0
54
0
0
7
0
0
67
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
60
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
7
0
0
0
0
0
0
20
7
% R
% Ser:
47
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% S
% Thr:
14
0
0
7
7
0
0
60
0
0
0
0
0
0
0
% T
% Val:
0
7
14
0
0
0
7
0
7
0
14
0
67
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
60
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _